Blar i forfatter "Skogen, Bjørn Ragnar"
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Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: A laboratory study using an in vitro model
Eksteen, Mariana; Heide, Gøril; Tiller, Heidi; Zhou, Yan; Nedberg, Nora Hersoug; Martinez-Zubiaurre, Inigo; Husebekk, Anne; Skogen, Bjørn Ragnar; Stuge, Tor Brynjar; Kjær, Mette (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-21)Background: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a bleeding disorder caused by maternal antibodies against paternal human platelet antigens (HPAs) on fetal platelets. Antibodies against HPA-1a are accountable for the majority of FNAIT cases. We have previously shown that high levels of maternal anti-HPA-1a antibodies are associated with clinically significant reduced birth ... -
Anti-human platelet antigen-1α immunoglobulin G preparation intended to prevent fetal and neonatal alloimmune thrombocytopenia
Weng, Ying-Jan; Husebekk, Anne; Skogen, Bjørn Ragnar; Killie, Mette Kjær; Lin, Liang-Tzung; Burnouf, Thierry (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-14)Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a severe disease that is caused by maternal alloantibodies generated during pregnancy or at delivery as a result of incompatibility between maternal and fetal human platelet antigens (HPAs) inherited from the father. Antibody-mediated immune suppression using anti-HPA-1a immunoglobulins is thought to be able to prevent FNAIT caused by ... -
Current perspectives on fetal and neonatal alloimmune thrombocytopenia - Increasing clinical concerns and new treatment opportunities
Tiller, Heidi; Husebekk, Anne; Ahlen, Maria Therese; Stuge, Tor Brynjar; Skogen, Bjørn Ragnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-19)Differences in platelet type between the fetus and the mother can lead to maternal immunization and destruction of the fetal platelets, a condition named fetal and neonatal alloimmune thrombocytopenia (FNAIT). FNAIT is reported to occur in ~1 per 1,000 live born neonates. The major risk is intracranial hemorrhage in the fetus or newborn, which is associated with severe neurological ... -
The development of severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies is correlated to maternal ABO genotypes
Ahlen, Maria Therese; Husebekk, Anne; Killie, Mette Kjær; Kjeldsen-Kragh, Jens; Olsson, Martin L.; Skogen, Bjørn Ragnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)Background. Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995–2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies. Design and Methods. A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, ... -
Fetal exposure to maternal human platelet antigen-1a does not induce tolerance. An analytical observational study
Kjær, Mette; Tiller, Heidi; Heide, Gøril; Kjeldsen-Kragh, Jens; Skogen, Bjørn Ragnar; Husebekk, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-24)Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a disease that may cause severe bleeding complications with risk of perinatal death or lifelong disability. The main cause of FNAIT is maternal antibodies against human platelet antigen (HPA)-1a. Both fetomaternal bleeding and transplacental trafficking of fetal cells during pregnancy could be the cause of alloimmunization. Persistence of ... -
Old tools revisited give hope - new treatment option for families with a history of severe FNAIT complications.
Tiller, Heidi; Fedorcsák, Péter; Skogen, Bjørn Ragnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-14) -
A prospective study of maternal anti-HPA1a antibody level as a potential predictor for alloimmune thrombocytopenia in the newborn
Husebekk, Anne; Killie, Mette Kjær; Kjeldsen-Kragh, Jens; Skogen, Bjørn Ragnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2008)